Paajanen Hannu, Julkunen Kristiina, Waris Heidi
Department of Surgery, Central Hospital of Mikkeli, 50100 Mikkeli, Finland.
J Clin Gastroenterol. 2005 Feb;39(2):110-4.
Our aim was to assess the long-term efficacy of diagnostic laparoscopy and adhesiolysis on the treatment of intractable chronic abdominal pain.
This was a prospective nonrandomized study of 72 patients (60 women and 12 men). One surgeon performed a total of 79 diagnostic laparoscopies including 61 adhesiolysis. The patients' demographic data, operative findings, and long-term postoperative course were carefully recorded. A quality-of-life questionnaire was mailed after the mean follow-up of 3.7 years to find out the late course of any chronic abdominal symptoms after the surgery.
Intra-abdominal adhesions were found in 61 patients (85%) in the laparoscopy, gynecologic disorders in 4, chronic appendicitis in 1, and no abnormality in 6 patients. The abdominal wall pain was a likely reason for pain in 12 patients (17%). The complication rate was minimal, including only four bleedings (one major), one perforation of urinary bladder, and three wound infections. At 1-month control, 38% of the patients were completely free of pain. In the long-term follow-up, chronic abdominal pain was totally healed in 33%, diminished in 46%, and unchanged in 21% of the patients. A total of 65 patients (90%) reported that the surgery had been beneficial for their intractable pain.
By careful selection, for patients with chronic abdominal pain, laparoscopy alleviates the symptoms in more than 70% of the patients, and it should be considered if other diagnostics tests are negative. A placebo-controlled study is needed, in which the patients are randomized into laparoscopy and conservatively treated groups with a quality-of-life measurement.
我们的目的是评估诊断性腹腔镜检查及粘连松解术治疗顽固性慢性腹痛的长期疗效。
这是一项对72例患者(60名女性和12名男性)进行的前瞻性非随机研究。一名外科医生共进行了79次诊断性腹腔镜检查,其中包括61次粘连松解术。仔细记录了患者的人口统计学数据、手术发现及术后长期病程。在平均随访3.7年后邮寄了一份生活质量问卷,以了解手术后任何慢性腹部症状的后期病程。
腹腔镜检查发现61例患者(85%)存在腹腔内粘连,4例有妇科疾病,1例有慢性阑尾炎,6例未发现异常。腹壁疼痛是12例患者(17%)疼痛的可能原因。并发症发生率极低,仅包括4例出血(1例严重)、1例膀胱穿孔和3例伤口感染。在1个月的复查中,38%的患者完全无疼痛。在长期随访中,33%的患者慢性腹痛完全治愈,46%的患者疼痛减轻,21%的患者疼痛无变化。共有65例患者(90%)报告手术对其顽固性疼痛有益。
通过仔细筛选,对于慢性腹痛患者,腹腔镜检查可使70%以上的患者症状得到缓解,若其他诊断检查结果为阴性,则应考虑采用该方法。需要进行一项安慰剂对照研究,将患者随机分为腹腔镜检查组和保守治疗组,并进行生活质量测量。