Bonnefous Céline, Vernier Jean-Michel, Hutchinson John H, Chung Janice, Reyes-Manalo Grace, Kamenecka Theodore
Department of Medicinal Chemistry, Merck Research Laboratories, MRLSDB2, 3535 General Atomics Court, San Diego, CA 92121, USA.
Bioorg Med Chem Lett. 2005 Feb 15;15(4):1197-200. doi: 10.1016/j.bmcl.2004.11.078.
The mGlu5 receptor has been implicated in a number of CNS disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amides as small molecules mGluR5 antagonists.
代谢型谷氨酸受体5（mGlu5）已被证实与多种中枢神经系统疾病有关。在此，我们报告了作为小分子mGluR5拮抗剂的联吡啶酰胺的发现、合成及生物学评价。
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