嗜肺军团菌中的Hfq同源物受LetA和RpoS调控，并与全局调节因子CsrA相互作用。
The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA.
作者信息
McNealy Tamara L, Forsbach-Birk Vera, Shi Chunwei, Marre Reinhard
机构信息
Department of Medical Microbiology and Hygiene, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.
出版信息
J Bacteriol. 2005 Feb;187(4):1527-32. doi: 10.1128/JB.187.4.1527-1532.2005.
Abstract
A gene in Legionella pneumophila that has significant homology to published hfq genes demonstrated regulation by RpoS and the transcriptional regulator LetA. Additionally, Hfq has a positive effect on the presence of transcripts of the genes for CsrA and the ferric uptake regulator Fur. Mutants lacking hfq demonstrate defects in growth and pigmentation and slight defects in virulence in both amoeba and macrophage infection models. Hfq appears to play a major role in exponential-phase regulatory cascades of L. pneumophila.
摘要
嗜肺军团菌中一个与已发表的hfq基因具有显著同源性的基因，显示出受RpoS和转录调节因子LetA调控。此外，Hfq对CsrA基因和铁摄取调节因子Fur的转录本的存在有积极影响。缺乏hfq的突变体在生长和色素沉着方面表现出缺陷，在变形虫和巨噬细胞感染模型中的毒力也有轻微缺陷。Hfq似乎在嗜肺军团菌的指数生长期调节级联反应中起主要作用。
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