Kim Kwan-Suk, Thomsen Hauke, Bastiaansen John, Nguyen Nguyet Thu, Dekkers Jack C M, Plastow Graham S, Rothschild Max F
Department of Animal Science and Center for Integrated Animal Genomics, Iowa State University, Ames, Iowa 50011-3150, USA.
Obes Res. 2004 Dec;12(12):1981-94. doi: 10.1038/oby.2004.249.
To investigate possible obesity candidate genes in regions of porcine quantitative trait loci (QTL) for fat deposition and obesity-related phenotypes.
Chromosome mapping and QTL analyses of obesity candidate genes were performed using DNA panels from a reference pig family. Statistical association analyses of these genes were performed for fat deposition phenotypes in several other commercial pig populations.
Eight candidate genes were mapped to QTL regions of pig chromosomes in this study. These candidate genes also served as anchor loci to determine homologous human chromosomal locations of pig fat deposition QTL. Preliminary analyses of relationships among polymorphisms of individual candidate genes and a variety of phenotypic measurements in a large number of pigs were performed. On the basis of available data, gene-gene interactions were also studied.
Comparative analysis of obesity-related genes in the pig is not only important for development of marker-assisted selection on growth and fat deposition traits in the pig but also provides for an understanding of their genetic roles in the development of human obesity.
研究猪脂肪沉积和肥胖相关表型的数量性状位点（QTL）区域中可能的肥胖候选基因。
使用来自一个参考猪家族的DNA样本进行肥胖候选基因的染色体定位和QTL分析。对其他几个商业猪群的脂肪沉积表型进行了这些基因的统计关联分析。
本研究中八个候选基因被定位到猪染色体的QTL区域。这些候选基因还作为锚定基因座来确定猪脂肪沉积QTL的同源人类染色体位置。对大量猪个体候选基因多态性与各种表型测量之间的关系进行了初步分析。基于现有数据，还研究了基因-基因相互作用。
猪中肥胖相关基因的比较分析不仅对猪生长和脂肪沉积性状的标记辅助选择的发展很重要，而且有助于理解它们在人类肥胖发生中的遗传作用。
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