四跨膜蛋白网络调节免疫信号复合物。

The tetraspanin web modulates immune-signalling complexes.

作者信息

Levy Shoshana, Shoham Tsipi

机构信息

Department of Medicine, Division of Oncology, Stanford University Medical Center, Stanford, California 94305, USA.

出版信息

Nat Rev Immunol. 2005 Feb;5(2):136-48. doi: 10.1038/nri1548.

DOI:10.1038/nri1548

PMID:15688041

Abstract

The tetraspanin web represents a new concept of molecular interactions in the immune system. Whereas most surface immune-modulating molecules involve receptor-ligand interactions, tetraspanins associate with partner proteins and facilitate their lateral positioning in the membrane. Moreover, the same tetraspanin molecule can associate with different proteins depending on the cell type. Most importantly, members of this family tend to associate with each other, together with their partners, in membrane microdomains that provide a scaffold for the transmission of external stimuli to intracellular-signalling components.

摘要

四跨膜蛋白网络代表了免疫系统中分子相互作用的一个新概念。大多数表面免疫调节分子涉及受体 - 配体相互作用，而四跨膜蛋白与伴侣蛋白结合，并促进它们在膜中的侧向定位。此外，同一四跨膜蛋白分子可根据细胞类型与不同蛋白质结合。最重要的是，该家族成员倾向于彼此以及与它们的伴侣在膜微区中结合，这些膜微区为外部刺激向细胞内信号传导成分的传递提供了一个支架。