p53：DNA修复与重组十字路口的交通警察。

p53: traffic cop at the crossroads of DNA repair and recombination.

作者信息

Sengupta Sagar, Harris Curtis C

机构信息

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37, Room 3068, Bethesda, Maryland, 20892-4255, USA.

出版信息

Nat Rev Mol Cell Biol. 2005 Jan;6(1):44-55. doi: 10.1038/nrm1546.

DOI:10.1038/nrm1546

PMID:15688066

Abstract

p53 mutants that lack DNA-binding activities, and therefore, transcriptional activities, are among the most common mutations in human cancer. Recently, a new role for p53 has come to light, as the tumour suppressor also functions in DNA repair and recombination. In cooperation with its function in transcription, the transcription-independent roles of p53 contribute to the control and efficiency of DNA repair and recombination.

摘要

缺乏DNA结合活性，因而也缺乏转录活性的p53突变体，是人类癌症中最常见的突变类型之一。最近，p53的一种新作用被发现，因为这种肿瘤抑制因子在DNA修复和重组中也发挥作用。与其转录功能协同，p53不依赖转录的作用有助于控制DNA修复和重组并提高其效率。