Keith Curtis T, Borisy Alexis A, Stockwell Brent R
CombinatoRx, Inc., 650 Albany Street, Boston, Massachusetts 02118, USA.
Nat Rev Drug Discov. 2005 Jan;4(1):71-8. doi: 10.1038/nrd1609.
Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most drug discovery efforts search for drugs that are composed of a single chemical entity. A focus in the early drug discovery process on identifying and optimizing the activity of combinations of molecules can result in the identification of more effective drug regimens. A systems perspective facilitates an understanding of the mechanism of action of such drug combinations.
包含不止一种活性成分的治疗方案在临床医学中普遍使用。尽管如此，大多数药物研发工作仍在寻找由单一化学实体构成的药物。在药物研发早期过程中专注于识别和优化分子组合的活性，可能会带来更有效的治疗方案。系统视角有助于理解此类药物组合的作用机制。
Zotero 插件