Kumar Veena V, Gaughan John, Isaacson Glenn, Szeremeta Wasyl
Departments of Otolaryngology-Head and Neck Surgery , Temple University School of Medicine, Philadelphia, PA 19140, USA.
Laryngoscope. 2005 Feb;115(2):363-5. doi: 10.1097/01.mlg.0000154746.55937.4d.
To compare the effectiveness of ciprofloxacin and oxymetazoline solutions instilled after tympanostomy tube placement in the prevention of postoperative otorrhea and tube occlusion.
Prospective cross-sectional series.
We reviewed all bilateral myringotomy and tube placement operations performed by two full-time attending pediatric otolaryngologists during a 9 month period. Data from 488 patients who underwent surgery for otitis media were collected. Demographic and clinical variables including age, sex, number of tube insertions in the past, previous adenoidectomy, type of effusion present at surgery, and type of drop prescribed postoperatively were recorded. All patients were evaluated in the office 2 to 4 weeks postoperatively. Multivariate logistic regression analysis was used to estimate the relationship of these variables with the occurrence of otorrhea and tube patency. Odds ratios were calculated.
No significant differences in postoperative otorrhea or tube patency were found between ciprofloxacin (Ciloxan) and oxymetazoline solutions (Afrin, Visine LR).
Oxymetazoline and ciprofloxacin solutions are equivalent in the prevention of postoperative otorrhea and tube occlusion after tympanostomy tube placement. The implications for medication cost and potential adverse reactions are discussed.
比较鼓膜置管术后滴入环丙沙星和羟甲唑啉溶液在预防术后耳漏和导管堵塞方面的有效性。
前瞻性横断面系列研究。
我们回顾了两位全职儿科耳鼻喉科主治医生在9个月期间进行的所有双侧鼓膜切开置管手术。收集了488例接受中耳炎手术患者的数据。记录人口统计学和临床变量，包括年龄、性别、既往置管次数、既往腺样体切除术、手术时存在的积液类型以及术后开具的滴剂类型。所有患者在术后2至4周在门诊接受评估。采用多因素逻辑回归分析来估计这些变量与耳漏发生和导管通畅之间的关系。计算比值比。
环丙沙星（西洛欣）和羟甲唑啉溶液（阿弗林、利福平眼药水）在术后耳漏或导管通畅方面无显著差异。
羟甲唑啉和环丙沙星溶液在预防鼓膜置管术后耳漏和导管堵塞方面效果相当。讨论了药物成本和潜在不良反应的影响。
Zotero 插件