Paxton A, Maine D, Freedman L, Fry D, Lobis S
Averting Maternal Death and Disability (AMDD) Program, Mailman School of Public Health, Columbia University, 60 Haven Avenue, New York, NY 10032, USA.
Int J Gynaecol Obstet. 2005 Feb;88(2):181-93. doi: 10.1016/j.ijgo.2004.11.026. Epub 2005 Jan 8.
We searched for evidence for the effectiveness of emergency obstetric care (EmOC) interventions in reducing maternal mortality primarily in developing countries.
We reviewed population-based studies with maternal mortality as the outcome variable and ranked them according to the system for ranking the quality of evidence and strength of recommendations developed by the US Preventive Services Task Force. A systematic search of published literature was conducted for this review, including searches of Medline, PubMed, Cochrane Database of Systematic Reviews, the Cochrane Pregnancy and Childbirth Database and the Cochrane Controlled Trials Register.
The strength of the evidence is high in several studies with a design that places them in the second and third tier in the quality of evidence ranking system. No studies were found that are experimental in design that would give them a top ranking, due to the measurement challenges associated with maternal mortality, although many of the specific individual clinical interventions that comprise EmOC have been evaluated through experimental design. There is strong evidence based on studies, using quasi-experimental, observational and ecological designs, to support the contention that EmOC must be a critical component of any program to reduce maternal mortality.
我们探寻了产科急诊(EmOC)干预措施在主要是发展中国家降低孕产妇死亡率方面有效性的证据。
我们回顾了以孕产妇死亡率为结果变量的基于人群的研究,并根据美国预防服务工作组制定的证据质量和推荐强度排名系统对这些研究进行排名。为本次综述对已发表文献进行了系统检索,包括检索Medline、PubMed、Cochrane系统评价数据库、Cochrane妊娠与分娩数据库以及Cochrane对照试验注册库。
在几项设计使其在证据质量排名系统中处于第二和第三层级的研究中,证据强度较高。由于与孕产妇死亡率相关的测量挑战,未发现设计为实验性的研究能使其获得最高排名,尽管构成EmOC的许多具体个体临床干预措施已通过实验设计进行了评估。基于采用准实验、观察性和生态学设计的研究,有强有力的证据支持EmOC必须是任何降低孕产妇死亡率项目的关键组成部分这一论点。