NOTCH1信号通路在急性白血病中发挥广泛作用。

A wide role for NOTCH1 signaling in acute leukemia.

作者信息

Chiaramonte Raffaella, Basile Andrea, Tassi Elena, Calzavara Elisabetta, Cecchinato Valentina, Rossi Vincenzo, Biondi Andrea, Comi Paola

机构信息

Department of Biomedical Science and Technology, University of Milano, LITA via Fratelli Cervi 93, 20090 Segrate, Milano, Italy.

出版信息

Cancer Lett. 2005 Feb 28;219(1):113-20. doi: 10.1016/j.canlet.2004.07.022.

DOI:10.1016/j.canlet.2004.07.022

PMID:15694671

Abstract

NOTCH1 is involved in the pathogenesis of T-acute lymphoblastic leukemia (T-ALL) carrying the very rare translocation t(7;9)(q34;q34.3). We analyzed the expression of genes belonging to NOTCH pathway, in acute leukemia primary samples and lymphoblastoid cell lines. NOTCH1 pathway activation represents a common feature of T-ALL when compared to acute myelogenous leukemia (AML) and B-cell precursor acute lymphoblastic leukemia. The contemporary expression of NOTCH1 and its ligands on cell surface contributes to high levels of pathway activity. AML primary samples show high levels of JAGGED1 expression despite the low NOTCH1 pathway activation, consistent with an autonomous JAGGED1 signaling in myeloid leukemogenesis.

摘要

NOTCH1参与携带极为罕见的t(7;9)(q34;q34.3)易位的T细胞急性淋巴细胞白血病（T-ALL）的发病机制。我们分析了急性白血病原代样本和淋巴母细胞系中属于NOTCH通路的基因表达。与急性髓细胞白血病（AML）和B细胞前体急性淋巴细胞白血病相比，NOTCH1通路激活是T-ALL的一个共同特征。NOTCH1及其配体在细胞表面的同时表达导致高水平的通路活性。尽管NOTCH1通路激活水平较低，但AML原代样本显示出高水平的JAGGED1表达，这与髓系白血病发生过程中JAGGED1的自主信号传导一致。