Zhou Jin, Chen Shi-Ling, Xing Fu-Qi, Pang Zhan-Jun, Li Bing, Zhou Wen-Qu, Fu Xin, Ding Yan-Qing
Department of Obstetriscs and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Feb;25(2):171-3.
To study the expressions of the novel gene F10 associated with hydatidiform mole in different trophoblastic tumors and explore the relation of F10 expression with the invasiveness of malignant trophoblastic tumor.
In situ hybridization was used to study the expression of F10 in 12 cases of hydatidiform mole, 6 cases of invasive mole, and 8 cases of choriocarcinoma.
F10 mRNA was positive in all cases of hydatidiform mole, invasive mole, and choriocarcinoma, and the expression intensity significantly increased in the order of hydatidiform mole, invasive mole and choriocarcinoma (P<0.001).
The expression of F10 gene may relate to the occurrence and invasiveness of trophoblastic tumor, with possible involvement in the invasion or malignant changes of trophoblastic cells.
研究与葡萄胎相关的新基因F10在不同滋养层肿瘤中的表达情况，并探讨F10表达与恶性滋养层肿瘤侵袭性的关系。
采用原位杂交技术研究F10在12例葡萄胎、6例侵蚀性葡萄胎和8例绒毛膜癌中的表达。
F10 mRNA在所有葡萄胎、侵蚀性葡萄胎和绒毛膜癌病例中均呈阳性，其表达强度按葡萄胎、侵蚀性葡萄胎和绒毛膜癌的顺序显著增加（P<0.001）。
F10基因的表达可能与滋养层肿瘤的发生和侵袭性有关，可能参与滋养层细胞的侵袭或恶性变化。
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