Duplication mitosis in epithelio-glandular tissue.

As duplication mitosis occurs in epithelio-glandular tissue, a different concept of histological continuity and organization of this tissue is needed. In epithelio-glandular tissue, duplication mitosis play a role in histological continuity, while maturation mitosis leads to histological organization. Duplication mitosis reproduces stem cells for the cell turnover process. The life-span of the cell copies is limited to a certain period by maturation mitosis. Conservation of duplication mitosis and its alteration to maturation mitosis are regulated by a histological mechanism in the gland crypt, involving duplication and maturation factors. The result is that epithelio-glandular tissue is maintained within a prescribed physiological volume without excessive multiplication.