Watanabe T, Sekiguchi K, Inoue A, Taniguchi Y, Sato S
Department of Neurosurgery, Yamagata Prefectural Central Hospital, Japan.
No Shinkei Geka. 1992 Apr;20(4):417-22.
Clinical characteristics and therapeutic problems of neurogenic pulmonary edema (NPE) occurring in the acute stage of severe subarachnoid hemorrhage (SAH) were examined. The relationship between SAH and NPE was studied in 208 patients who arrived at the hospital in the acute stage (within 24 hours after the onset) of severe SAH in the past nine years. NPE was observed in four (6%) of 64 Grade III patients, nine (18%) of 49 Grade IV patients and 20 (21%) of 95 Grade V patients. Higher grade patients tended to be complicated by NPE more frequently. CT findings of these 33 patients with NPE belonged to Fisher's Group 3 or 4 (23 of 110 group-3 patients and 10 of 88 group-4 patients). Concerning ECG abnormalities, depression of ST segment, abnormal T waves, sinus tachycardia, and right bundle-branch block were observed more frequently in the NPE group than in the non-NPE group. In comparison of the age, blood pressure, PaO2, serum electrolyte, WBC, and blood sugar level on admission between the two groups, significantly higher values of diastolic pressure and blood sugar levels were shown in the NPE group than non-NPE group. The mean interval between the onset of SAH and the diagnosis of NPE on chest film was 2.5 hours, while the NPE findings disappeared within three days after the onset of SAH (mean 1.2 days). In all cases, the NPE findings disappeared after a variety of respiratory managements had been carried out.(ABSTRACT TRUNCATED AT 250 WORDS)
研究了重症蛛网膜下腔出血(SAH)急性期发生的神经源性肺水肿(NPE)的临床特征及治疗问题。对过去九年中在重症SAH急性期(发病后24小时内)入院的208例患者进行了SAH与NPE关系的研究。在64例Ⅲ级患者中有4例(6%)出现NPE,49例Ⅳ级患者中有9例(18%),95例Ⅴ级患者中有20例(21%)。分级较高的患者更容易并发NPE。这33例NPE患者的CT表现属于Fisher 3级或4级(110例3级患者中的23例和88例4级患者中的10例)。关于心电图异常,NPE组比非NPE组更频繁地观察到ST段压低、T波异常、窦性心动过速和右束支传导阻滞。比较两组患者入院时的年龄、血压、动脉血氧分压、血清电解质、白细胞和血糖水平,NPE组的舒张压和血糖水平显著高于非NPE组。SAH发病至胸部X线片诊断NPE的平均间隔时间为2.5小时,而NPE表现于SAH发病后三天内消失(平均1.2天)。在所有病例中,经过各种呼吸管理后,NPE表现均消失。(摘要截短至250字)