一种用于计算系统生物学的形式语言。
A formal language for computational systems biology.
作者信息
Errampalli Daniel D, Priami Corrado, Quaglia Paola
机构信息
Department of Information and Telecommunication, University of Trento, Povo, Italy.
出版信息
OMICS. 2004 Winter;8(4):370-80. doi: 10.1089/omi.2004.8.370.
The post-genomic era has opened new insights into the complex biochemical reaction systems present in the cell and has generated huge amount of information. The biological systems are highly complex and can overwhelm the numerically computable models. Therefore, models employing symbolical techniques might provide a faster insight. This paper presents some preliminary results and recent trends in the above direction. Specifically, it presents an overview of the main features of some formalisms and techniques from the field of specification languages for concurrency and mobility, which have been proposed to model and simulate the dynamics of the interaction of complex biological systems. The ultimate goal of these symbolic approaches is the modeling, analysis, simulation, and hopefully prediction of the behavior of biological systems (vs. biological components).
后基因组时代为深入了解细胞中存在的复杂生化反应系统开辟了新途径,并产生了大量信息。生物系统高度复杂,可能使数值可计算模型不堪重负。因此,采用符号技术的模型可能会提供更快的见解。本文介绍了上述方向的一些初步结果和最新趋势。具体而言,它概述了并发与移动性规范语言领域中一些形式主义和技术的主要特征,这些形式主义和技术已被提出用于对复杂生物系统相互作用的动态进行建模和模拟。这些符号方法的最终目标是对生物系统(相对于生物组件)的行为进行建模、分析、模拟,并有望进行预测。