[血管组织工程中内皮细胞抗血栓功能的研究]
[Study of antithrombotic function of endothelium in vascular tissue engineering].
作者信息
Zheng Lei, Wang Qian
机构信息
Department of Clinical Laboratory, Southern Medical University (the First Military Medical University), Guangzhou Guangdong 510515, P R China.
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2005 Jan;19(1):74-7.
OBJECTIVE
To investigate the current situation and developing trend of antithrombotic function study of endothelium in vascular tissue engineering.
METHODS
The effect of several elements on the antithrombotic ability of endothelium, including the source of endothelium, the characteristic of the matrix materials, the cell culture methods, and the endothelium's gene modification were analyzed.
RESULTS
The normal antithrombotic function of tissue engineered vascular relied on the source of endothelium, gene modification of seeding cells, the cell culture methods in vitro, and the characteristic of the scaffolds.
CONCLUSION
The establishment of an ideal antithrombotic functional tissue engineering vascular still requires further studies in various aspects including seeding cells, matrix materials, and cell culture methods. Gene modification of vascular endothelium, which improves the antithrombotic ability, deserves more attention.
目的
探讨血管组织工程中内皮抗血栓功能研究的现状及发展趋势。
方法
分析了几种因素对内皮抗血栓能力的影响，包括内皮来源、基质材料特性、细胞培养方法以及内皮的基因修饰。
结果
组织工程血管的正常抗血栓功能依赖于内皮来源、接种细胞的基因修饰、体外细胞培养方法以及支架特性。
结论
建立理想的具有抗血栓功能的组织工程血管仍需要在接种细胞、基质材料和细胞培养方法等各个方面进行进一步研究。改善抗血栓能力的血管内皮基因修饰值得更多关注。
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