Shapiro Mark, McDonald Amy A, Knight Douglas, Johannigman Jay A, Cuschieri Joseph
Department of Surgery, University of Massachusetts, Boston, MA, USA.
J Trauma. 2005 Feb;58(2):227-31. doi: 10.1097/01.ta.0000152080.97337.1f.
Angiographic embolization has emerged as the treatment modality of choice for bleeding pelvic fractures. The purpose of this study is to identify potential indicators for ongoing pelvic hemorrhage despite initial therapeutic or non-diagnostic angiography.
The trauma registry of a Level I trauma center was used to identify patients with pelvic fractures between January 2000 and June 2002. Records were reviewed for demographics, severity of injury, hemodynamic status, initial and subsequent base deficit, blood and fluid requirements, length of stay, and mortality. Statistical analysis was performed using Student's t test, and univariate and multivariate analysis, significance was assigned to p < or = 0.05.
During the study period, 678 patients had pelvic fractures. Angiography was performed in 31 (4.6%) of these patients. Arterial hemorrhage was diagnosed initially on 16 (51.6%) patients requiring embolization. Three (18.8%) of these embolized patients required repeat angiography and embolization due to ongoing pelvic hemorrhage. Of the initial 15 patients with negative angiograms, five (33.3%) had repeat angiograms due to continued hypotension and acidosis. Four (80.0%) of these five patients were found to have arterial hemorrhage requiring embolization. Of the seven (22.6%) patients requiring repeat angiography for control of ongoing pelvic hemorrhage, three independent factors were predictive: continued or recurrent hypotension (SBP < 90), absence of intra-abdominal injury, and persistent base deficit of 10 for greater than 6 hours. The presence of all three independent predictors was associated with a 97% probability of pelvic bleeding (p = 0.001).
Angiographic embolization is highly effective in controlling arterial bleeding associated with pelvic fractures. However, repeat angiography should be performed in patients with pelvic fractures with ongoing evidence of hemorrhage demonstrated by persistent base deficit and hypotension once other potential sources of bleeding have been excluded.
血管造影栓塞术已成为骨盆骨折出血的首选治疗方式。本研究的目的是确定尽管进行了初始治疗性或非诊断性血管造影,但仍存在持续性骨盆出血的潜在指标。
使用一级创伤中心的创伤登记系统来识别2000年1月至2002年6月期间的骨盆骨折患者。回顾记录中的人口统计学、损伤严重程度、血流动力学状态、初始和后续碱缺失、血液和液体需求量、住院时间及死亡率。采用学生t检验进行统计分析,并进行单因素和多因素分析,p≤0.05具有统计学意义。
在研究期间,678例患者发生骨盆骨折。其中31例(4.6%)患者接受了血管造影。最初在16例(51.6%)需要栓塞的患者中诊断出动脉出血。这些接受栓塞治疗的患者中有3例(18.8%)因持续性骨盆出血需要重复血管造影和栓塞。在最初血管造影阴性的15例患者中,5例(33.3%)因持续低血压和酸中毒进行了重复血管造影。这5例患者中有4例(80.0%)被发现存在需要栓塞的动脉出血。在7例(22.6%)因控制持续性骨盆出血而需要重复血管造影的患者中,有三个独立因素具有预测性:持续或反复低血压(收缩压<90)、无腹腔内损伤以及持续碱缺失≥10超过6小时。所有这三个独立预测因素的存在与骨盆出血可能性为97%相关(p = 0.001)。
血管造影栓塞术在控制与骨盆骨折相关的动脉出血方面非常有效。然而,一旦排除其他潜在出血源,对于有持续出血证据(表现为持续性碱缺失和低血压)的骨盆骨折患者,应进行重复血管造影。