Li Jun, Dong An-jie
Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Zhongguo Zhong Yao Za Zhi. 2004 Mar;29(3):193-6.
Nanoparticles had received much attention in the development of new kind of pharmaceutical formation because of the special nano-effectivity. Recently, some studies discovered the special functions of the nanoparticles in transdermal and transmucosal drug delivery systems. Even though the acting mechanism of the nanoparticles in these drug delivery systems are not known, these discoveries of the special function of the nanoparticles provide new developing prospect to the drug delivery systems. This paper mainly reviews the present studying results about the nanoparticles used in the transdermal and transmucosal drug delivery systems, including the lipid nanopaticles, natural polymer and the synthesized polymer nanoparticles.
由于特殊的纳米效应,纳米粒子在新型药物制剂的开发中备受关注。最近,一些研究发现了纳米粒子在经皮和经粘膜给药系统中的特殊功能。尽管纳米粒子在这些给药系统中的作用机制尚不清楚,但这些关于纳米粒子特殊功能的发现为给药系统提供了新的发展前景。本文主要综述了目前关于纳米粒子在经皮和经粘膜给药系统中应用的研究结果,包括脂质纳米粒、天然聚合物和合成聚合物纳米粒。