慢性疼痛与胸外科手术。

Chronic pain and thoracic surgery.

作者信息

Erdek Michael A, Staats Peter S

机构信息

Division of Pain Medicine, The Johns Hopkins University School of Medicine, 550 North Broadway, Suite 301, Baltimore, MD 21205, USA.

出版信息

Thorac Surg Clin. 2005 Feb;15(1):123-30. doi: 10.1016/j.thorsurg.2004.10.001.

DOI:10.1016/j.thorsurg.2004.10.001

PMID:15707350

Abstract

The development of chronic pain after thoracic surgery is a particularly undesirable yet common complication. As the study of the pathophysiology of chronic pain with regard to the plasticity of the central nervous system advances, new insights are being gained into not only the potential origins of chronic postthoracotomy pain, but also its potential treatment options. Pain that is originally nociceptive in nature in the acute postoperative period after thoracotomy may become neuropathic in time, requiring a different paradigm for its treatment. The ongoing research into the development of chronic pain, including that observed after thoracic surgery, portends the development of further advances in options for its control. The employment of multidisciplinary strategies of pharmacologic, behavioral, and interventional procedural techniques provides the current foundation for the management of this challenging condition.

摘要

胸外科手术后慢性疼痛的发生是一种特别不良但常见的并发症。随着关于中枢神经系统可塑性的慢性疼痛病理生理学研究的进展，人们不仅对开胸术后慢性疼痛的潜在根源，而且对其潜在治疗方案都有了新的认识。开胸术后急性期原本具有伤害感受性的疼痛可能会随着时间推移转变为神经病理性疼痛，需要采用不同的治疗模式。对慢性疼痛发生机制的持续研究，包括胸外科手术后观察到的情况，预示着在其控制方法上会有进一步进展。运用药物、行为和介入程序技术的多学科策略为管理这一具有挑战性的病症提供了当前的基础。