用于功能磁共振成像潜在应用的快速光谱成像策略。

Fast spectroscopic imaging strategies for potential applications in fMRI.

作者信息

Mulkern Robert V, Chen Nan-kuei, Oshio Koichi, Panych Lawrence P, Rybicki Frank J, Gambarota Giulio

机构信息

Department of Radiology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Magn Reson Imaging. 2004 Dec;22(10):1395-405. doi: 10.1016/j.mri.2004.10.011.

DOI:10.1016/j.mri.2004.10.011

PMID:15707789

Abstract

Technical aspects of two general fast spectroscopic imaging (SI) strategies, one based on gradient echo trains and the other on spin echo trains, are reviewed within the context of potential applications in the field of functional magnetic resonance imaging (fMRI). Fast spectroscopic imaging of water may prove useful for identifying mechanisms underlying the blood oxygenation level dependence (BOLD) of the water signal during brain activation studies. Reasonably rapid mapping of changes in proton signals from brain metabolites, like lactate, creatine or even neurotransmitter associated metabolites like GABA, is substantially more challenging but technically feasible particularly as higher field strengths become available. Fast spectroscopic methods directed towards the 31P signals from phosphocreatine (PCr) and adenosine tri-phosphates (ATP) are also technically feasible and may prove useful for studying cerebral energetics within fMRI contexts.

摘要

在功能磁共振成像（fMRI）领域的潜在应用背景下，对两种通用的快速光谱成像（SI）策略的技术方面进行了综述，一种基于梯度回波序列，另一种基于自旋回波序列。在脑部激活研究中，水的快速光谱成像可能有助于识别水信号的血氧水平依赖性（BOLD）背后的机制。对来自脑代谢物（如乳酸、肌酸）甚至与神经递质相关的代谢物（如GABA）的质子信号变化进行合理快速的映射，更具挑战性，但在技术上是可行的，特别是随着更高场强的实现。针对磷酸肌酸（PCr）和三磷酸腺苷（ATP）的31P信号的快速光谱方法在技术上也是可行的，并且可能被证明对在fMRI背景下研究脑能量学有用。