Guarnieri Ricardo, Wichert-Ana Lauro, Hallak Jaime E C, Velasco Tonicarlo R, Walz Roger, Kato Mery, Alexandre Veriano, Terra-Bustamante Vera C, Bianchin Marino M, Zuardi Antonio W, Deakin John F W, Sakamoto Américo C
Center for Epilepsy Surgery-CIREP, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, 3900, CEP 14.048-900, Ribeirão Preto, SP, Brazil.
Psychiatry Res. 2005 Jan 30;138(1):75-84. doi: 10.1016/j.pscychresns.2004.10.003.
Psychosis is commonly observed in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS). Interictal single photon emission computed tomography (SPECT) was performed to compare regional cerebral blood flow (rCBF) pattern of MTLE-HS patients with psychosis of epilepsy (POE) comorbidity and MTLE-HS patients without any psychiatric disorders (Control group). For this, 21 patients with POE and 23 Control patients were matched by educational level, clinical, demographic, electrophysiological, and MRI data. SPECT scans were acquired using (99m)Tc and interpreted with a semiquantitative method. We analyzed brain regions of interest (ROI) of frontal, temporal, and parietal cortex, in addition to subcortical structures. There were no significant statistical differences of ROI between the POE group and the Control group after Bonferroni adjustment. However, we observed a trend for rCBF increase of right posterior cingulate in the POE Group. This increase would be in accordance with recent findings of cingulate abnormalities in schizophrenia, suggesting that abnormal function in this region might be associated with the psychotic phenomena.
精神病常见于与海马硬化相关的内侧颞叶癫痫（MTLE-HS）患者中。进行发作间期单光子发射计算机断层扫描（SPECT）以比较合并癫痫性精神病（POE）的MTLE-HS患者与无任何精神障碍的MTLE-HS患者（对照组）的局部脑血流（rCBF）模式。为此，通过教育水平、临床、人口统计学、电生理和MRI数据对21例POE患者和23例对照患者进行匹配。使用（99m）Tc进行SPECT扫描并用半定量方法进行解释。除皮质下结构外，我们还分析了额叶、颞叶和顶叶皮质的感兴趣脑区（ROI）。经Bonferroni校正后，POE组和对照组之间的ROI无显著统计学差异。然而，我们观察到POE组右侧后扣带回的rCBF有增加趋势。这种增加与精神分裂症中扣带回异常的最新发现一致，表明该区域的功能异常可能与精神病现象有关。
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