小鼠γ-疱疹病毒68开放阅读框11编码一种非必需的病毒体成分。
Murine gammaherpesvirus 68 open reading frame 11 encodes a nonessential virion component.
作者信息
Boname Jessica M, May Janet S, Stevenson Philip G
机构信息
Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Rd., Cambridge CB2 1QP, United Kingdom.
出版信息
J Virol. 2005 Mar;79(5):3163-8. doi: 10.1128/JVI.79.5.3163-3168.2005.
Abstract
Open reading frame 11 (ORF11) is a conserved gammaherpesvirus gene that remains undefined. We identified the product of murine gammaherpesvirus 68 (MHV-68) ORF11, p43, as a virion component with a predominantly perinuclear distribution in infected cells. MHV-68 lacking p43 grew normally in vitro but showed reduced lytic replication in vivo and a delay in seeding to the spleen. Subsequent latency amplification was normal. Thus, MHV-68 ORF11 encoded a virion component that was important for in vivo lytic replication but dispensable for the establishment of latency.
摘要
开放阅读框11（ORF11）是一种保守的γ疱疹病毒基因，其功能尚不清楚。我们鉴定出鼠γ疱疹病毒68（MHV-68）的ORF11产物p43是一种病毒体成分，在感染细胞中主要分布于核周。缺乏p43的MHV-68在体外生长正常，但在体内的裂解复制减少，且在播种到脾脏时出现延迟。随后的潜伏扩增正常。因此，MHV-68的ORF11编码一种病毒体成分，该成分对体内裂解复制很重要，但对潜伏的建立并非必需。
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2
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6
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Microbes Infect. 2002 Sep;4(11):1177-82. doi: 10.1016/s1286-4579(02)01643-x.
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