(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives as melatoninergic agents.
作者信息
Sun Li-Qiang, Takaki Katherine, Chen Jie, Bertenshaw Stephen, Iben Lawrence, Mahle Cathy D, Ryan Elaine, Wu Dedong, Gao Qi, Xu Cen
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492, USA.
出版信息
Bioorg Med Chem Lett. 2005 Mar 1;15(5):1345-9. doi: 10.1016/j.bmcl.2005.01.015.
PMID:15713384
Abstract
(R)-2-(4-Phenylbutyl)dihydrobenzofuran derivatives (e.g., 3 and 4) were synthesized as novel melatoninergic ligands with significantly lower vasoconstrictive activity in vitro in the rat tail artery. Binding affinity assays were performed on cloned human MT1 and MT2 receptors stably expressed in NIH3T3 cells.
摘要
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