[载水飞蓟素固体脂质纳米粒（SM-SLN）的冷冻干燥]
[Freeze-drying of silymarin-loaded solid lipid nanoparticles (SM-SLN)].
作者信息
He Jun, Feng Jian-fang, Zhang Le-le, Lu Wei-gen, Hou Shi-xiang
机构信息
West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2005 Jan;30(2):110-2.
OBJECTIVE
To investigate lyophilization of SM-SLN.
METHOD
The parameters of lyophilization process was optimized. In addition, the protective effect of various types and concentrations of cryoprotectants were tested by shape, colour and disparity.
RESULT
The mixture of 2% lactose and 2% glucose could better prevent nanoparticles from aggregating, the optimal lyophilization process was followed: precooled at -45 degrees C for 10 hr; primary drying at -25 degrees C for 5 hr; secondary drying at 10 degrees C for 3 hr; finally drying at 30 degrees C for 6 hr.
CONCLUSION
Changes in particle size distribution during lyophilization could be minimized by optimizing the parameters of the lyophilization process and adding supporting agent.
目的
研究SM-SLN的冻干过程。
方法
对冻干过程参数进行优化。此外，通过形状、颜色和差异测试了各种类型和浓度的冻干保护剂的保护效果。
结果
2%乳糖和2%葡萄糖的混合物能更好地防止纳米颗粒聚集，最佳冻干过程如下：在-45℃预冷10小时；在-25℃进行一次干燥5小时；在10℃进行二次干燥3小时；最后在30℃干燥6小时。
结论
通过优化冻干过程参数并添加支持剂，可将冻干过程中粒径分布的变化降至最低。
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