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美国社区实践中确诊为子宫体癌的女性的术前影像学检查、手术及辅助治疗

Pre-operative imaging, surgery and adjuvant therapy for women diagnosed with cancer of the corpus uteri in community practice in the United States.

作者信息

Trimble Edward L, Harlan Linda C, Clegg Limin X, Stevens Jennifer L

机构信息

National Cancer Institute, Surgery Section, 6130 Executive Boulevard, Ste. 741, M., Bethesda, MD 20892-7436, USA.

出版信息

Gynecol Oncol. 2005 Mar;96(3):741-8. doi: 10.1016/j.ygyno.2004.11.041.

Abstract

INTRODUCTION

Non-Hispanic black women are less often diagnosed with endometrial cancer than are non-Hispanic white women, but are more likely to die of their disease. Reasons for this disparity in outcome are not well understood.

METHODS

The Surveillance, Epidemiology, and End-Results Program data were used to sample women newly diagnosed in 1998 with cancer of the corpus uteri. A total of 711 women with no previous diagnosis of cancer were selected. Women with sarcoma were not eligible for the study. We then sought to verify the therapy provided each woman with her treating physician.

RESULTS

Non-Hispanic black women were diagnosed with higher stage, grade, poor histologic subtype, and greater extension of the tumor than were non-Hispanic white women. Hispanic women were diagnosed with more favorable tumor characteristics than non-Hispanic black women, but less favorable than non-Hispanic white women. The use of radiation and chemotherapy increased with stage.

CONCLUSIONS

Our study did not show any difference in recommended therapy for women with uterine adenocarcinoma among NH black women, NH white women, and Hispanic women. We must look for other factors, therefore, to explain the disparities in cancer outcome observed among NH black women with endometrial cancer.

摘要

引言

与非西班牙裔白人女性相比,非西班牙裔黑人女性被诊断出子宫内膜癌的几率较低,但死于该病的可能性更高。这种结果差异的原因尚不完全清楚。

方法

利用监测、流行病学和最终结果计划的数据,对1998年新诊断为子宫体癌的女性进行抽样。总共选取了711名此前未被诊断出患有癌症的女性。患有肉瘤的女性不符合该研究的条件。然后,我们试图向每位女性的主治医生核实其接受的治疗。

结果

与非西班牙裔白人女性相比,非西班牙裔黑人女性被诊断出的癌症分期更高、分级更高、组织学亚型较差且肿瘤扩散范围更大。西班牙裔女性被诊断出的肿瘤特征比非西班牙裔黑人女性更有利,但比非西班牙裔白人女性更不利。放疗和化疗的使用随分期增加。

结论

我们的研究未显示非西班牙裔黑人女性、非西班牙裔白人女性和西班牙裔女性在子宫腺癌治疗建议上存在任何差异。因此,我们必须寻找其他因素来解释在患有子宫内膜癌的非西班牙裔黑人女性中观察到的癌症结果差异。

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