新型萘基秋水仙酰胺。乙烯桥的修饰。
New naphthylcombretastatins. Modifications on the ethylene bridge.
作者信息
Sánchez Maya Ana B, Pérez-Melero Concepción, Salvador Nélida, Peláez Rafael, Caballero Esther, Medarde Manuel
机构信息
Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
出版信息
Bioorg Med Chem. 2005 Mar 15;13(6):2097-107. doi: 10.1016/j.bmc.2005.01.012.
Compounds with three aromatic systems, carrying a 2-naphthalene and a 3,4,5-trimethoxyphenyl moieties bonded to five-membered, six-membered or fused heterocycles display potent cytotoxic effect and inhibition of tubulin polymerization, in agreement with their structural similarity to combretastatins and their heterocyclic analogues.
含有三个芳香体系、带有与五元、六元或稠合杂环相连的2-萘基和3,4,5-三甲氧基苯基部分的化合物表现出强大的细胞毒性作用以及对微管蛋白聚合的抑制作用，这与其与康普他汀及其杂环类似物的结构相似性一致。
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