Jonas R, Asarnow R F, LoPresti C, Yudovin S, Koh S, Wu J Y, Sankar R, Shields W D, Vinters H V, Mathern G W
Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, USA.
Neurology. 2005 Feb 22;64(4):746-50. doi: 10.1212/01.WNL.0000151970.29205.70.
Children undergoing surgery with infant-onset epilepsy were classified into those with medically refractory infantile spasms (IS), successfully treated IS, and no IS history, and the groups were compared for pre- and postsurgery clinical and Vineland Adaptive Behavior Scale (VABS) developmental quotients (DQ). Children without an IS history were older at surgery and had longer epilepsy durations than those with IS despite similar substrates, surgeries, and seizure frequencies. In all groups, better postsurgery VABS-DQ scores were associated with early surgical intervention indicating that infant-onset epilepsy patients with or without IS are at risk for seizure-induced encephalopathy.
接受手术治疗的婴儿期起病癫痫患儿被分为药物难治性婴儿痉挛症（IS）组、IS得到成功治疗组和无IS病史组，对这些组别的术前和术后临床情况以及文兰适应性行为量表（VABS）发育商（DQ）进行比较。尽管癫痫发作的基础、手术及发作频率相似，但无IS病史的患儿手术时年龄更大，癫痫病程更长。在所有组中，术后VABS-DQ得分更高与早期手术干预相关，这表明有或无IS的婴儿期起病癫痫患者有发生癫痫性脑病的风险。
