Barry A L, Cohen M A, Sesnie J C, Fuchs P C, Washington J A, Murray P R, Baker C
Clinical Microbiology Institute, Tualatin, Oregon 97062.
J Clin Microbiol. 1992 Apr;30(4):813-6. doi: 10.1128/jcm.30.4.813-816.1992.
For testing the susceptibility of Neisseria gonorrhoeae to enoxacin, a proposed susceptibility category includes strains for which MICs are less than or equal to 0.5 micrograms/ml and zones of inhibition are greater than or equal to 32 mm in diameter. Because of the sparcity of resistant gonococci, a resistance category was not defined, but laboratory-selected resistant mutants were appropriately categorized by the proposed criteria. A review of clinical data confirmed the utility of a single 400-mg oral dose of enoxacin for treating gonorrhea caused by strains judged to be susceptible by the proposed criteria. For quality control purposes, for N. gonorrhoeae ATCC 49226 MICs should be 0.016 to 0.06 micrograms/ml and zones of inhibition should be 43 to 51 mm in diameter.
为检测淋病奈瑟菌对依诺沙星的敏感性，一个提议的敏感性分类包括 MIC 小于或等于 0.5 微克/毫升且抑菌圈直径大于或等于 32 毫米的菌株。由于耐药淋病奈瑟菌稀少，未定义耐药分类，但实验室筛选出的耐药突变体按提议标准进行了适当分类。对临床数据的回顾证实了单次口服 400 毫克依诺沙星治疗由按提议标准判定为敏感的菌株引起的淋病的效用。出于质量控制目的，对于淋病奈瑟菌 ATCC 49226，MIC 应为 0.016 至 0.06 微克/毫升，抑菌圈直径应为 43 至 51 毫米。
