5-Lipoxygenase as a putative mechanism of NSAID-related psychiatric adverse events.

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作者信息

Manev Radmila, Manev Hari

出版信息

Drugs. 2005;65(4):577. doi: 10.2165/00003495-200565040-00009.

DOI:10.2165/00003495-200565040-00009

PMID:15733016

Abstract

摘要

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本文引用的文献

Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.骨关节炎软骨细胞中5-脂氧合酶激活蛋白/5-脂氧合酶表达的调控及白三烯B4的合成：转化生长因子β和类花生酸的作用

Arthritis Rheum. 2004 Dec;50(12):3925-33. doi: 10.1002/art.20632.

5-Lipoxygenase as a putative link between cardiovascular and psychiatric disorders.5-脂氧合酶作为心血管疾病与精神疾病之间的一种潜在联系。

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The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.编码5-脂氧合酶激活蛋白的基因会增加心肌梗死和中风的风险。

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5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior.5-脂氧合酶（5LOX）缺陷型小鼠表现出减少的焦虑样行为。

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