Khorasani M T, Zaghiyan M, Mirzadeh H
Biomaterial Department of Iran Polymer and Petrochemical Institute, P.O. Box 14185/458, Tehran 14965115, Iran.
Colloids Surf B Biointerfaces. 2005 Mar 25;41(2-3):169-74. doi: 10.1016/j.colsurfb.2004.12.007. Epub 2005 Jan 19.
An acetabular cup shock absorber implant is formed from a composite of polymer materials. The cup consists of three zones such as the articulating surface of the implant is 100% ultra high molecular weight polyethylene (UHMWPE) (zone 1) and shock absorber of the cup contains of polydimethylsiloxane (PDMS) (zone 3). Zone 2 which is designed for better adhesion between zone 1 and zone 2 consists of a blend of UHMWPE and PDMS is a cushion that from one side adheres to zone 1 and the other side to zone 2. PDMS and UHMWPE have been blended under conditions of shear and elevated temperature in order to form uniform, thermoplastic blends. When blends compared to pure UHMWPE, the blends show lowered tensile modulus and lowered mixing energies. The UHMWPE crystals are increased in quantity or else become more regular, even 50% blend shows no rubbery stage. The morphology and dynamic mechanical behavior of the blends were studied using scanning electron microscopy (SEM) and dynamic mechanic thermal analysis (DMTA). In this study, the biocompatibility have evaluated in vitro the interaction of UHMWPE, silicone and PDMS/UHMWPE blends with L929 fibroblast cells.
髋臼杯减震植入物由聚合物材料复合材料制成。该杯体由三个区域组成,例如植入物的关节表面为100%超高分子量聚乙烯(UHMWPE)(区域1),杯体的减震器包含聚二甲基硅氧烷(PDMS)(区域3)。区域2旨在使区域1和区域2之间具有更好的附着力,它由UHMWPE和PDMS的混合物组成,是一个从一侧附着于区域1而另一侧附着于区域3的垫子。PDMS和UHMWPE在剪切和高温条件下进行了混合,以形成均匀的热塑性混合物。与纯UHMWPE相比,混合物的拉伸模量降低,混合能也降低。UHMWPE晶体数量增加或变得更加规则,即使是50%的混合物也没有橡胶态阶段。使用扫描电子显微镜(SEM)和动态力学热分析(DMTA)研究了混合物的形态和动态力学行为。在本研究中,已经在体外评估了UHMWPE、硅酮和PDMS/UHMWPE混合物与L929成纤维细胞的相互作用的生物相容性。