34条全长HIV-1亚型间重组序列的重新分析

Re-analysis of 34 full-length HIV-1 intersubtype recombinant sequences.

作者信息

Magiorkinis G, Paraskevis D, Magiorkinis E, Vandamme A-M, Hatzakis A

机构信息

National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Mikras Asias 75, 11527 Athens, Greece.

出版信息

Infect Genet Evol. 2005 Apr;5(3):225-9. doi: 10.1016/j.meegid.2004.05.010. Epub 2004 Dec 7.

DOI:10.1016/j.meegid.2004.05.010

PMID:15737913

Abstract

One of the main characteristics of the HIV-1 is its extensive genetic heterogeneity. Intersubtype recombination was first described in 1995 and since then a significant proportion of the HIV-1 isolates was found to comprise mosaic sequences. Re-analysis of 34 full-length HIV-1 intersubtype recombinants, including all "pure" HIV-1 subtypes revealed that 19 of the 34 analyzed mosaics consist of a more complex mosaic pattern than initially described. These findings indicate that the complexity of the HIV-1 recombinants is much greater than previously estimated.

摘要

HIV-1的主要特征之一是其广泛的遗传异质性。亚型间重组于1995年首次被描述，从那时起，发现相当一部分HIV-1分离株包含镶嵌序列。对34个全长HIV-1亚型间重组体（包括所有“纯”HIV-1亚型）的重新分析表明，在分析的34个镶嵌体中，有19个的镶嵌模式比最初描述的更为复杂。这些发现表明，HIV-1重组体的复杂性比先前估计的要大得多。