Green Jeffrey E, Hudson Tamaro
Transgenic Oncogenesis Group, Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Besthesda, MD 20892, USA.
Nat Rev Cancer. 2005 Mar;5(3):184-98. doi: 10.1038/nrc1565.
Sophisticated genetic technologies have led to the development of mouse models of human cancers that recapitulate important features of human oncogenesis. Many of these genetically engineered mouse models promise to be very relevant and relatively rapid systems for determining the efficacy of chemopreventive agents and their mechanisms of action. The validation of such models for chemoprevention will help the selection of appropriate agents for large-scale clinical trials and allow the testing of combination therapies.
先进的基因技术推动了人类癌症小鼠模型的发展，这些模型概括了人类肿瘤发生的重要特征。许多这类基因工程小鼠模型有望成为非常相关且相对快速的系统，用于确定化学预防剂的疗效及其作用机制。对这类化学预防模型的验证将有助于为大规模临床试验选择合适的药物，并允许对联合疗法进行测试。
