Buckley Peter F, Dean David, Bookstein Fred L, Han Seungho, Yerukhimovich Michael, Min Kyoung-June, Singer Beth
Department of Psychiatry and Health Behavior, Medical College of Georgia, 1515 Pope Ave., Augusta, GA 30912-3800, USA.
Am J Psychiatry. 2005 Mar;162(3):606-8. doi: 10.1176/appi.ajp.162.3.606.
Subtle dysmorphogenesis of the craniofacial region constitutes important corroborating evidence of the neurodevelopmental origins of schizophrenia. Advances in facial visualization now allow for three-dimensional anthropometric evaluations of potentially greater discriminatory power in examining the complex geometric relationships of facial topography.
Sixty-five anthropometrically derived landmarks were identified from three-dimensional facial images collected from 14 patients with schizophrenia and 11 comparison subjects, imaged with a high-resolution, portable laser scanner.
Using the Procrustes morphometric approach for shape analysis, the difference in mean shapes was highly significant, with patients exhibiting superoinferior elongation of the face.
The topography of craniofacial anomalies in schizophrenia is not random and points to midline deformation.
颅面部区域细微的畸形发生是精神分裂症神经发育起源的重要佐证。面部可视化技术的进步使得在检查面部地形复杂几何关系时能够进行三维人体测量评估，其具有更大的鉴别力。
从14例精神分裂症患者和11名对照受试者采集的三维面部图像中识别出65个人体测量得出的标志点，这些图像由高分辨率便携式激光扫描仪成像。
采用普洛克斯变换形态测量方法进行形状分析，平均形状差异非常显著，患者面部表现为上下方向的伸长。
精神分裂症患者颅面部异常的地形并非随机，而是指向中线变形。
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