Gianini Nicole M, Vieira Alan A, Moreira Maria Elizabeth Lopes
Instituto Fernandes Figueiras, FIOCRUZ, Rio de Janeiro, RJ.
J Pediatr (Rio J). 2005 Jan-Feb;81(1):34-40.
To evaluate the nutritional status at term of a cohort of newborn babies with birth weights of less than 1,500 g and to correlate this with nutritional practices and clinical variables.
Very low birth weight infants admitted to eight neonatal intensive care units from November 1999 to April 2000 were studied prospectively. The units were defined as Type I if they employed aggressive nutritional support techniques and Type II if other nutritional practices were used. Babies were defined as malnourished if their z-score for weight was less than or equal to -2 on the Canadian Perinatal Surveillance System growth curves. Data were analyzed using multivariate linear regression and logistic regression. The study was approved by the Committee for Ethics in Research.
Sixty-three percent (126/200) of the study population were classified as being malnourished at term. Weight at term (corrected gestational age) showed a direct correlation with birth weight, but an indirect correlation with the length of stay, gestational age at birth, time to regain birth weight and CRIB score (p < 0.05). Small for gestational age infants had a 12.19 times greater chance of being malnourished at term. Being born at a Type I unit reduced the risk of malnutrition at term by 2.17 times, male sex reduced this risk by 0.4 times and achieving total enteral nutrition by the 10th day of life reduced it by 1.97 times (p < 0.03).
The most effective means of preventing babies being malnourished at term is by encouraging perinatal practices aimed at preventing restricted intrauterine growth, in addition to giving priority to aggressive nutritional management.
评估一组出生体重低于1500克的足月新生儿的营养状况,并将其与营养实践和临床变量相关联。
对1999年11月至2000年4月入住8个新生儿重症监护病房的极低出生体重儿进行前瞻性研究。如果采用积极的营养支持技术,则将这些病房定义为I型;如果采用其他营养实践,则定义为II型。如果婴儿在加拿大围产期监测系统生长曲线上的体重z评分小于或等于-2,则定义为营养不良。使用多元线性回归和逻辑回归分析数据。该研究获得了研究伦理委员会的批准。
研究人群中有63%(126/200)在足月时被归类为营养不良。足月时的体重(校正胎龄)与出生体重呈正相关,但与住院时间、出生时胎龄、恢复出生体重的时间和CRIB评分呈负相关(p<0.05)。小于胎龄儿足月时营养不良的可能性高12.19倍。在I型病房出生可使足月时营养不良的风险降低2.17倍,男性可使该风险降低0.4倍,在出生后第10天实现完全肠内营养可使该风险降低1.97倍(p<0.03)。
预防足月婴儿营养不良的最有效方法是鼓励采取围产期措施以防止宫内生长受限,此外还要优先进行积极的营养管理。