Brackbill Marcia L, Moberg Lori
Department of Pharmacy Practice, Bernard J. Dunn School of Pharmacy, Winchester, VA 22601, USA.
Am J Health Syst Pharm. 2005 Feb 15;62(4):397-9. doi: 10.1093/ajhp/62.4.0397.
The effects of i.v. magnesium sulfate on the frequency of postoperative atrial fibrillation (AF) in patients undergoing coronary artery bypass grafting (CABG) and on the frequency of AF at hospital discharge were studied. The effect of postoperative AF on hospital length of stay (LOS) was also assessed.
A retrospective chart review was performed for all patients who underwent CABG surgery by a single surgeon during 2000-2001 at a community medical center. Patients were eligible for inclusion if they had first-time CABG surgery. Patients who underwent CABG surgery in 2000 did not receive magnesium sulfate and served as controls for the study. Patients were included in the magnesium group if they received 2 g of i.v. magnesium sulfate intraoperatively and 2 g every 12 hours postoperatively for at least two consecutive days.
A total of 262 patients underwent CABG during the study period, and 28 were excluded from the study. Of the remaining 234 patients, 99 were in the magnesium group, and 135 were in the control group. No significant differences were found between the study groups in recorded demographic characteristics. Postoperative AF occurred significantly less frequently in the magnesium group (p = 0.038). There was no significant difference between treatment groups in the number of patients discharged in AF (p = 0.307). Among all patients, those with AF were significantly more likely to have a prolonged LOS (p = 0.036).
CABG patients who received intraoperative and postoperative i.v. magnesium sulfate had a significantly lower rate of AF compared with patients who did not receive the drug. The number of patients discharged with AF was not affected by magnesium administration. AF was associated with a higher likelihood of prolonged postoperative hospitalization.
研究静脉注射硫酸镁对冠状动脉旁路移植术（CABG）患者术后房颤（AF）发生率及出院时房颤发生率的影响。同时评估术后房颤对住院时间（LOS）的影响。
对2000 - 2001年在一家社区医疗中心由单一外科医生进行CABG手术的所有患者进行回顾性病历审查。首次进行CABG手术的患者符合纳入标准。2000年接受CABG手术的患者未接受硫酸镁，作为研究对照。术中接受2 g静脉注射硫酸镁且术后至少连续两天每12小时接受2 g硫酸镁的患者纳入硫酸镁组。
研究期间共有262例患者接受CABG手术，28例被排除在研究之外。其余234例患者中，99例在硫酸镁组，135例在对照组。研究组在记录的人口统计学特征方面未发现显著差异。硫酸镁组术后房颤发生率显著较低（p = 0.038）。治疗组之间房颤出院患者数量无显著差异（p = 0.307）。在所有患者中，发生房颤的患者住院时间延长的可能性显著更高（p = 0.036）。
与未接受该药物的患者相比，术中及术后接受静脉注射硫酸镁的CABG患者房颤发生率显著更低。硫酸镁给药未影响房颤出院患者数量。房颤与术后住院时间延长的可能性更高相关。
