Bergamini Valentino, Ghezzi Fabio, Cromi Antonella, Bellini Gaia, Zanconato Giovanni, Scarperi Stefano, Franchi Massimo
Department of Obstetrics and Gynecology, University of Verona, Italy.
Am J Obstet Gynecol. 2005 Mar;192(3):768-73. doi: 10.1016/j.ajog.2004.10.591.
The purpose of this study was to evaluate the feasibility and efficacy of laparoscopic radiofrequency ablation of uterine fibroids.
Eighteen women with symptomatic intramural uterine myomas underwent radiofrequency ablation under laparoscopic guidance. Postoperative sonographic evaluations of the fibroids size were scheduled at 1, 3, 6 ,9, and 12 months. The impact of myoma-related symptoms on quality of life (QOL) was assessed using a validated questionnaire.
The median number of myomas treated per patient was 1 (1-3). The median baseline volume of the dominant myoma was 67.2 cm 3 (14.8-332.8). No intraoperative or postoperative complications occurred. The median reductions in myomas volume were 41.5%, 59%, and 77% at 1, 3, and 6-months, follow-up evaluation, respectively. No further change in fibroid size was observed at 9 months and 1 year. A significant improvement in the symptoms score and QOL score was observed at 3 and 6 months, follow-up.
In this pilot study, laparoscopic radiofrequency ablation successfully reduced fibroid symptoms and fibroid volume in short-term follow-up. Additional studies are needed before its efficacy and safety can be confirmed.
本研究旨在评估腹腔镜下子宫肌瘤射频消融术的可行性和疗效。
18例有症状的肌壁间子宫肌瘤女性患者在腹腔镜引导下接受射频消融术。术后分别在1、3、6、9和12个月安排对肌瘤大小进行超声评估。使用经过验证的问卷评估肌瘤相关症状对生活质量（QOL）的影响。
每位患者治疗肌瘤的中位数为1个（1 - 3个）。优势肌瘤的基线体积中位数为67.2立方厘米（14.8 - 332.8）。未发生术中或术后并发症。在1、3和6个月的随访评估中，肌瘤体积的中位数减少分别为41.5%、59%和77%。在9个月和1年时未观察到肌瘤大小有进一步变化。在3个月和6个月随访时，症状评分和生活质量评分有显著改善。
在这项初步研究中，腹腔镜射频消融术在短期随访中成功减轻了肌瘤症状并缩小了肌瘤体积。在其疗效和安全性得到证实之前，还需要进一步研究。
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