复发性呼吸道乳头状瘤病患者的发病率、发病年龄及恶变的潜在原因：20年经验

Incidence, age at onset, and potential reasons of malignant transformation in recurrent respiratory papillomatosis patients: 20 years experience.

作者信息

Gerein Valentin, Rastorguev Eugen, Gerein Johann, Draf Wolfgang, Schirren Joachim

机构信息

Department of Pediatric Pathology, Institute of Pathology, University of Mainz, Germany.

出版信息

Otolaryngol Head Neck Surg. 2005 Mar;132(3):392-4. doi: 10.1016/j.otohns.2004.09.035.

DOI:10.1016/j.otohns.2004.09.035

PMID:15746849

Abstract

Forty-two patients with recurrent respiratory papillomatosis (RRP) were accepted into a multicenter prospective study in 1983 to 1990, treated with alfa-IFN 3 MU/m 2 3 times a week and then followed-up until August 1, 2003. All the patients who had disease progression with pulmonary spread were characterized by insufficient response to IFN-therapy and detection of HPV type 11. Five patients (4/5 smokers) presented malignant transformation in lungs or nasopharynx (mean RRP duration was 27.2 +/- 8 years from RRP onset and 14.6 +/- 6.3 years from pulmonary spread until malignant transformation) with persistent RRP in larynx. The results of long-term follow-up in RRP patients with HPV 11 underline the necessity of reanalyzing the current therapy.

摘要

1983年至1990年，42例复发性呼吸道乳头状瘤病（RRP）患者被纳入一项多中心前瞻性研究，接受α-干扰素3 MU/m²每周3次的治疗，随后进行随访直至2003年8月1日。所有疾病进展至肺部扩散的患者均表现为对干扰素治疗反应不足且检测到11型人乳头瘤病毒（HPV）。5例患者（4/5为吸烟者）出现肺部或鼻咽部恶性转化（从RRP发病至恶性转化，RRP平均病程为27.2±8年，从肺部扩散至恶性转化为14.6±6.3年），喉部RRP持续存在。对HPV 11型RRP患者的长期随访结果强调了重新分析当前治疗方法的必要性。