Dinca-Avarvarei L, Patrignani-Ochoa J H, Castilla-Garrido J M, Jiménez-Castellano Ballesteros R, Ugarte-Monasterio J
Servicio de Neurología, Hospital Universitario Virgen Macarena, 41003 Sevilla, España.
Rev Neurol. 2005;40(3):141-4.
Single fibre electromyography (SFEMG) is a method that complements conventional electromyography and studies the activity of individual muscle fibres and of the neuromuscular junction. AIMS. We attempt to demonstrate the presence of reinnervation disorders by studying Jitter, fibre density (FD) and the presence of neurogenic blocks in patients with amyotrophic lateral sclerosis (ALS).
SFEMG was carried out on 18 patients diagnosed with ALS. All the patients were submitted to a voluntary SFEMG in the extensor digitorum communis muscle of the fingers on the most affected side.
The SFEMG in the extensor digitorum communis muscle of the fingers showed alterations in 13 out of the 18 patients studied (72%). FD was the most reliable parameter for translation of the motor neuron instability and increased in all cases. This was followed by the mean and the maximum individual (62%) Jitter and, lastly, the percentage of blocks (38%).
In ALS, the parameters studied with SFEMG were modified in 72% of the cases studied. There is an overall correlation between the length of time the patient has had the disease and the modifications in the SFEMG (21.5 versus 13.7 months). The degree of clinical involvement is higher (6.5/13) in those who present an altered SFEMG compared to those who present a normal SFEMG (5.3/13).
单纤维肌电图（SFEMG）是一种补充传统肌电图的方法，用于研究单个肌纤维和神经肌肉接头的活动。目的：我们试图通过研究肌萎缩侧索硬化症（ALS）患者的颤抖、纤维密度（FD）和神经源性阻滞的存在来证明再支配障碍的存在。
对18例诊断为ALS的患者进行了SFEMG检查。所有患者均在受影响最严重一侧手指的指总伸肌上进行了自愿性SFEMG检查。
在所研究的18例患者中，有13例（72%）手指指总伸肌的SFEMG显示有改变。FD是反映运动神经元不稳定最可靠的参数，在所有病例中均增加。其次是平均和最大个体颤抖（62%），最后是阻滞百分比（38%）。
在ALS中，在所研究的病例中有72%的病例，用SFEMG研究的参数发生了改变。患者患病时间长短与SFEMG改变之间存在总体相关性（21.5个月对13.7个月）。与SFEMG正常的患者（5.3/13）相比，SFEMG异常的患者临床受累程度更高（6.5/13）。
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