Mikolaenko Irina, Pletnikova Olga, Kawas Claudia H, O'Brien Richard, Resnick Susan M, Crain Barbara, Troncoso Juan C
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2196, USA.
J Neuropathol Exp Neurol. 2005 Feb;64(2):156-62. doi: 10.1093/jnen/64.2.156.
Alpha-synuclein (alpha-synuclein) lesions are characteristic of idiopathic Parkinson disease (PD) and other alpha-synucleinopathies. To study the frequency of alpha-synuclein lesions in normal aging and how frequently they coexist with lesions of Alzheimer disease (AD), we examined the autopsy brains from normal and demented subjects in the Baltimore Longitudinal Study of Aging (BLSA) (n = 117). We found that the overall frequency of alpha-synuclein lesions was 25%, with 100% in 7 cases of PD, 31.5% in 56 cases with AD lesions, and 8.3% among 36 older control brains. Among brains with AD lesions, the frequency of alpha-synuclein pathology was higher in those with higher scores for neuritic plaques, but not in those with higher scores for neurofibrillary tangles. Our observations indicate that alpha-synuclein lesions are uncommon in aged control subjects. Finally, the coexistence of Abeta amyloid and alpha-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Abeta and alpha-synuclein may be similar.
α-突触核蛋白病变是特发性帕金森病（PD）和其他α-突触核蛋白病的特征。为了研究正常衰老过程中α-突触核蛋白病变的发生率以及它们与阿尔茨海默病（AD）病变共存的频率，我们检查了巴尔的摩衰老纵向研究（BLSA）中正常和痴呆受试者的尸检大脑（n = 117）。我们发现，α-突触核蛋白病变的总体发生率为25%，7例PD患者中为100%，56例有AD病变的患者中为31.5%，36例老年对照大脑中为8.3%。在有AD病变的大脑中，α-突触核蛋白病理学的发生率在神经炎性斑块得分较高的大脑中更高，但在神经原纤维缠结得分较高的大脑中并非如此。我们的观察结果表明，α-突触核蛋白病变在老年对照受试者中并不常见。最后，AD大脑中β淀粉样蛋白和α-突触核蛋白病理学的共存表明，导致β淀粉样蛋白和α-突触核蛋白积累的致病机制可能相似。
Zotero 插件