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乳腺癌女性的门诊基因风险评估:一个中心的经验

Outpatient genetic risk assessment in women with breast cancer: one center's experience.

作者信息

Washburn Nancy J, Sommer Valerie K, Spencer Sarah E, Simmons Sandra K, Adkins Barbara W, Rogers Mary R, Gerken Patty L, Bromley Christina M

机构信息

Kansas City Cancer Center South, Missouri, USA.

出版信息

Clin J Oncol Nurs. 2005 Feb;9(1):49-53. doi: 10.1188/05.CJON.49-53.

Abstract

A chart audit at one cancer center, of 193 women with breast cancer, was completed to assess whether a complete family history that may indicate genetic predisposition was obtained and if that information led a provider to suggest risk reduction strategies. A risk management tool, which included a pedigree template, was used. Of the 193 charts reviewed, 88.6% had family history information recorded; 41.5% reported three generations of family history. Risk management was undocumented in 21.8% of the charts reviewed and, for those that were reported (78.2%), 7.25% were referred for genetic counseling. These results suggest that a more detailed assessment of hereditary breast cancer risk incorporating three generations of family history and additional types of cancer need to be integrated into medical oncology practice. An algorithm was developed as a guide to improve the process of evaluation and referral for genetic risk assessment.

摘要

一家癌症中心对193名乳腺癌女性患者的病历进行了审核,以评估是否获取了可能表明遗传易感性的完整家族史,以及该信息是否促使医疗服务提供者提出降低风险的策略。使用了一种包括系谱模板的风险管理工具。在审查的193份病历中,88.6%记录了家族史信息;41.5%报告了三代家族史。在21.8%的审查病历中,风险管理无记录,而在有记录的病历(78.2%)中,7.25%被转诊进行遗传咨询。这些结果表明,需要将纳入三代家族史和其他癌症类型的更详细的遗传性乳腺癌风险评估纳入肿瘤内科实践。开发了一种算法作为改进遗传风险评估的评估和转诊流程的指南。

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