Zhang Yao-Jun, Chen Min-Shan, Liang Hui-Hong, Xu Li, Zhang Ya-Qi
Department of Hepatobiliary Tumor, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P.R.China.
Ai Zheng. 2005 Mar;24(3):365-7.
BACKGROUND & OBJECTIVE: Primary hepatic lymphoma (PHL), a rare malignancy, has seldom been reported. This article was to investigate clinicopathologic features and treatment of PHL.
Data of 4 patients with PHL, treated in Cancer Center, Sun Yat-sen University from Nov. 1994 to May 2004, were retrospectively analyzed.
Of the 4 patients, 3 were men, and 1 was woman, with a median age of 53 years old; 3 had single focus, and 1 had multi-foci. All patents were positive for HBV antigen, 3 were misdiagnosed preoperatively, and 1 had no clear diagnosis before operation. Pathologic examination revealed that 3 were B-cell non-Hodgkin's lymphoma, and 1 was Hodgkin's lymphoma. Two patients received resection, and 2 received biopsy; all patients received adjuvant chemotherapy postoperatively.
HBV infection might relate with the development of PHL. PHL should be considered for the patients presented liver mass and B-symptomatolgy. Resection followed by adjuvant chemotherapy with CHOP regiment seems to be the best option for PHL.
原发性肝淋巴瘤（PHL）是一种罕见的恶性肿瘤，鲜有报道。本文旨在探讨PHL的临床病理特征及治疗方法。
回顾性分析1994年11月至2004年5月在中山大学肿瘤防治中心治疗的4例PHL患者的数据。
4例患者中，男性3例，女性1例，中位年龄53岁；3例为单发病灶，1例为多发病灶。所有患者乙肝抗原均为阳性，3例术前误诊，1例术前未明确诊断。病理检查显示，3例为B细胞非霍奇金淋巴瘤，1例为霍奇金淋巴瘤。2例患者接受了手术切除，2例接受了活检；所有患者术后均接受了辅助化疗。
HBV感染可能与PHL的发生有关。对于出现肝脏肿块和B症状的患者应考虑PHL。手术切除后联合CHOP方案辅助化疗似乎是PHL的最佳选择。
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