Keener J P
Department of Mathematics, University of Utah, 155 South 1400 East, Salt Lake City, UT 84112, USA.
J Theor Biol. 2005 May 21;234(2):263-75. doi: 10.1016/j.jtbi.2004.11.022. Epub 2005 Jan 20.
We present a mathematical model for the growth and length regulation of the hook component of the flagellar motor of Salmonella typhimurium. Under the assumption that the molecular constituents are translocated into the nascent filament by an ATP-ase and then move by molecular diffusion to the growing end, where they polymerize into the growing tube, we find that there is a detectable transition from secretion limited growth to diffusion limited growth. We propose that this transition can be detected by the secretant FliK, allowing FliK to interact with FlhB thereby changing the secretion target of the type III secretion machinery and terminating the growth of the hook.
我们提出了一个关于鼠伤寒沙门氏菌鞭毛马达钩组件生长和长度调节的数学模型。假设分子成分由ATP酶转运到新生丝中,然后通过分子扩散移动到生长末端,在那里它们聚合成生长管,我们发现存在从分泌限制生长到扩散限制生长的可检测转变。我们提出,这种转变可由分泌蛋白FliK检测到,从而使FliK与FlhB相互作用,改变III型分泌机制的分泌靶点并终止钩的生长。