铅作业工人中髌骨铅及其他铅生物标志物与肾功能的关联。

Associations of patella lead and other lead biomarkers with renal function in lead workers.

作者信息

Weaver Virginia M, Lee Byung-Kook, Todd Andrew C, Jaar Bernard G, Ahn Kyu-Dong, Wen Jiayu, Shi Weiping, Parsons Patrick J, Schwartz Brian S

机构信息

Division of Occupational and Environmental Health, Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA.

出版信息

J Occup Environ Med. 2005 Mar;47(3):235-43. doi: 10.1097/01.jom.0000155971.10111.6d.

DOI:10.1097/01.jom.0000155971.10111.6d

PMID:15761319

Abstract

OBJECTIVE

We sought to compare associations of patella lead, which may represent a unique cumulative and bioavailable lead pool, with other lead measures in models of renal function.

METHODS

Renal function measures included blood urea nitrogen, serum creatinine, measured and calculated creatinine clearances, and urinary N-acetyl-beta-D-glucosaminidase (NAG) and retinol-binding protein.

RESULTS

In 652 lead workers, mean (SD) blood, patella, and tibia lead were 30.9 (16.7) microg/dL, 75.1 (101.1) and 33.6 (43.4) microg Pb/g bone mineral, respectively, and were correlated (Spearman's r = 0.51-0.74). Patella lead was associated (P < 0.05) with NAG in all lead workers. In models of effect modification by age, higher patella lead also was associated with higher serum creatinine in older participants. Similar associations were observed for blood and tibia lead.

CONCLUSIONS

Associations between patella lead and adverse renal outcomes were not unique; this may be due, in part, to high correlations among the lead biomarkers in this study.

摘要

目的

我们试图在肾功能模型中比较髌骨铅（可能代表一个独特的累积且具有生物利用性的铅池）与其他铅测量指标之间的关联。

方法

肾功能测量指标包括血尿素氮、血清肌酐、测量和计算的肌酐清除率，以及尿N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）和视黄醇结合蛋白。

结果

在652名铅作业工人中，血铅、髌骨铅和胫骨铅的均值（标准差）分别为30.9（16.7）μg/dL、75.1（101.1）和33.6（43.4）μg Pb/g骨矿物质，且它们之间具有相关性（Spearman相关系数r = 0.51 - 0.74）。在所有铅作业工人中，髌骨铅与NAG相关（P < 0.05）。在按年龄进行效应修饰的模型中，较高的髌骨铅在老年参与者中也与较高的血清肌酐相关。血铅和胫骨铅也观察到类似的关联。