视网膜母细胞瘤：动物模型

Retinoblastoma: animal models.

作者信息

Conway R Max, Wheeler Sharon M, Murray Timothy G, Jockovich Maria-Elena, O'Brien Joan M

机构信息

Ocular Oncology Unit, Department of Ophthalmology, University of California, San Francisco, 10 Koret Way, Box 0730, Room K-304, San Francisco, CA 94143-0730, USA.

出版信息

Ophthalmol Clin North Am. 2005 Mar;18(1):25-39, vii. doi: 10.1016/j.ohc.2004.08.006.

DOI:10.1016/j.ohc.2004.08.006

PMID:15763189

Abstract

Employment of animal models in basic research has significantly advanced the understanding of fundamental processes underlying tumorigenesis in retinoblastoma, including elucidating the complex role of pRb and other related protein products in cell cycle regulation, apoptosis, DNA damage responses, and terminal differentiation. The evolution of therapy for retinoblastoma has also been facilitated through translational research using in vivo models, including xenograft and genetically engineered systems. In retinoblastoma, these models provide a valuable preclinical context for testing the efficacy and safety of conventional chemotherapy, radiotherapy, or novel agents on tumor growth, tissue invasion, and metastasis.

摘要

在基础研究中使用动物模型显著推进了对视网膜母细胞瘤肿瘤发生基本过程的理解，包括阐明视网膜母细胞瘤结合蛋白（pRb）和其他相关蛋白产物在细胞周期调控、细胞凋亡、DNA损伤反应及终末分化中的复杂作用。通过使用体内模型（包括异种移植和基因工程系统）进行转化研究，也推动了视网膜母细胞瘤治疗方法的发展。在视网膜母细胞瘤中，这些模型为测试传统化疗、放疗或新型药物对肿瘤生长、组织侵袭和转移的疗效及安全性提供了有价值的临床前背景。