非耗竭性抗CD4抗体不仅能预防发病，还能治愈NOD小鼠的涎腺炎。

Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice.

作者信息

Thompson Clare, Jacobsen Helle, Pomeranz Krummel Daniel, Nagai Kyoshi, Cooke Anne

机构信息

Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.

出版信息

Autoimmunity. 2004 Dec;37(8):549-54. doi: 10.1080/08916930400021352.

DOI:10.1080/08916930400021352

PMID:15763917

Abstract

The non-obese diabetic (NOD) mouse spontaneously develops lymphocytic infiltrates in the salivary glands (sialadenitis) and provides an useful rodent model of human Sjogren's syndrome (SS). Non-depleting anti-CD4 antibodies have been shown to ameliorate Type 1 diabetes in NOD mice and also vasculitis in MRL/lpr mice. This study shows that a short course of treatment with the non-depleting anti-CD4 monoclonal antibody, YTS 177, completely prevents salivary infiltration and reverses ongoing pathology in the salivary gland.

摘要

非肥胖糖尿病（NOD）小鼠会自发地在唾液腺出现淋巴细胞浸润（涎腺炎），并提供了一种有用的人类干燥综合征（SS）啮齿动物模型。已表明非耗竭性抗CD4抗体可改善NOD小鼠的1型糖尿病以及MRL/lpr小鼠的血管炎。本研究表明，用非耗竭性抗CD4单克隆抗体YTS 177进行短期治疗可完全防止唾液腺浸润，并逆转唾液腺中正在发生的病理状况。