Guasch E, Suárez A, Bermejo J M, Gilsanz F
Servicio de Anestesia y Reanimación, Hospital Universitario La Paz (Maternidad), Madrid.
Rev Esp Anestesiol Reanim. 2005 Feb;52(2):75-80.
Spinal anesthesia is the technique most often applied in cases of scheduled cesarean section. Many authors have tried decreasing the local anesthetic dose by adding opioids to achieve adequate analgesia with greater hemodynamic stability, although the ideal dose remains to be established. Our aim was to analyze hemodynamic stability and quality of analgesia with 2 different regimens for administering spinal hyperbaric bupivacaine.
We designed a controlled, double-blind trial comparing 2 doses of spinal hyperbaric bupivacaine with fentanyl in 42 patients undergoing elective cesarean section randomized to 2 groups to receive either the low dose or the conventional one. One group received an 11 mg dose of bupivacaine and the other group received a 6.5 mg dose, combined with 20 microg of fentanyl in both cases.
The hemodynamic profile and the level of maximum sensory block obtained were similar in the two groups. The motor block was less intense in patients receiving the lower dose and it was necessary to convert 2 patients (10%) to general anesthesia in that group.
Spinal anesthesia with low doses of bupivacaine and fentanyl provides acceptable intraoperative conditions for a high percentage of patients undergoing cesarean section, with a similar incidence of hypotension. The low dose generates a less intense intraoperative motor blockade with similar spread of the sensory block. The low dose was not efficacious for 10% of the patients who received it.
脊髓麻醉是择期剖宫产手术中最常应用的技术。许多作者尝试通过添加阿片类药物来减少局部麻醉剂剂量,以在血流动力学更稳定的情况下实现充分镇痛,尽管理想剂量仍有待确定。我们的目的是分析两种不同方案给予脊髓高压布比卡因时的血流动力学稳定性和镇痛质量。
我们设计了一项对照双盲试验,比较42例行择期剖宫产手术的患者随机分为两组,分别接受低剂量或传统剂量的脊髓高压布比卡因与芬太尼。一组接受11毫克布比卡因剂量,另一组接受6.5毫克剂量,两组均联合20微克芬太尼。
两组的血流动力学特征和获得的最大感觉阻滞水平相似。接受较低剂量的患者运动阻滞较轻,该组中有2名患者(10%)需要转为全身麻醉。
低剂量布比卡因和芬太尼的脊髓麻醉为高比例的剖宫产患者提供了可接受的术中条件,低血压发生率相似。低剂量产生的术中运动阻滞较轻,感觉阻滞范围相似。低剂量对10%接受该剂量的患者无效。