具有血栓素A2拮抗活性的抗过敏药物KW4099的合成与旋光拆分
Synthesis and optical resolution of an antiallergic agent KW4099 with thromboxane A2 antagonistic activity.
作者信息
Sugaya T, Kuge Y, Tomioka S, Tamaki K
机构信息
Sakai Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Osaka, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1992 Jan;40(1):238-9. doi: 10.1248/cpb.40.238.
PMID:1576677
Abstract
A new antiallergic agent with thromboxane A2 antagonistic activity, KW4099, was synthesized by a simple method. Its optical resolution was accomplished with the use of (+)- or (-)-2,2'-(1,1'-binaphthyl)phosphoric acid as a resolving agent.
摘要
一种具有血栓素A2拮抗活性的新型抗过敏剂KW4099，通过一种简单方法合成。其光学拆分是使用(+)-或(-)-2,2'-(1,1'-联萘基)磷酸作为拆分剂完成的。
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