日本人群中吸烟与卵巢癌风险：日本协作队列研究的结果

Cigarette smoking and the risk of ovarian cancer in the Japanese population: findings from the Japanese Collaborate Cohort study.

作者信息

Niwa Yoshimitsu, Wakai Kenji, Suzuki Sadao, Tamakoshi Koji, Lin Yingsong, Yatsuya Hiroshi, Kondo Takaaki, Nishio Kazuko, Yamamoto Akio, Tokudome Shinkan, Hamajima Nobuyuki, Toyoshima Hideaki, Tamakoshi Akiko

机构信息

Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan.

出版信息

J Obstet Gynaecol Res. 2005 Apr;31(2):144-51. doi: 10.1111/j.1447-0756.2005.00261.x.

DOI:10.1111/j.1447-0756.2005.00261.x

PMID:15771641

Abstract

AIM

The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988.

METHODS

A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders.

RESULTS

Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] x number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044).

CONCLUSIONS

These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.

摘要

目的

众多关于吸烟与卵巢癌风险关系的研究结果并不一致。在此，我们利用1988年启动的日本癌症风险评估协作队列研究的数据，对这一关系进行了调查。

方法

34639名日本女性完成了一份关于吸烟习惯及其他癌症风险因素的自填式问卷。经过7.6年的随访，有39例卵巢癌病例可供分析。采用Cox比例风险模型计算相对风险（RR）并对混杂因素进行校正。

结果

与从不吸烟的女性相比，既往吸烟者患卵巢癌的RR为1.63（95%置信区间[CI]=0.21 - 12.50），当前吸烟者为2.27（95%CI = 0.85 - 6.08）。在当前吸烟者中，相对于从不吸烟的女性，每天吸烟<10支、10 - 19支以及至少20包年（[每天吸烟支数/20]×吸烟年数）的女性患卵巢癌的RR分别为1.48（95%CI = 0.20 - 10.92）、5.56（95%CI = 1.68 - 19.06）和1.86（95%CI = 0.25 - 14.30）。趋势检验具有统计学意义（P = 0.044）。