Soj拮抗枯草芽孢杆菌中Spo0A对转录的激活作用。
Soj antagonizes Spo0A activation of transcription in Bacillus subtilis.
作者信息
McLeod Brett N, Spiegelman George B
机构信息
Department of Microbiology and Immunology, University of British Columbia, 6174 University Blvd., Vancouver, British Columbia V6T 1Z3, Canada.
出版信息
J Bacteriol. 2005 Apr;187(7):2532-6. doi: 10.1128/JB.187.7.2532-2536.2005.
Abstract
The ParA family protein Soj appears to negatively regulate sporulation in Bacillus subtilis by inhibiting transcription from promoters that are activated by phosphorylated Spo0A. We tested in vitro Soj inhibition of Spo0A-independent variants of a promoter that Soj inhibited (PspoIIG). Transcription from the variants was less sensitive to Soj inhibition, suggesting that inhibition of wild-type PspoIIG was linked to transcription activation by Spo0A.
摘要
ParA家族蛋白Soj似乎通过抑制由磷酸化Spo0A激活的启动子的转录来负向调节枯草芽孢杆菌的芽孢形成。我们在体外测试了Soj对其抑制的一个启动子（PspoIIG）的Spo0A非依赖性变体的抑制作用。这些变体的转录对Soj抑制的敏感性较低，这表明野生型PspoIIG的抑制与Spo0A的转录激活有关。
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