接触木屑与肺癌风险的关联。

Wood dust exposure and the association with lung cancer risk.

作者信息

Barcenas Carlos H, Delclos George L, El-Zein Randa, Tortolero-Luna Guillermo, Whitehead Lawrence W, Spitz Margaret R

机构信息

Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77225-0186, USA.

出版信息

Am J Ind Med. 2005 Apr;47(4):349-57. doi: 10.1002/ajim.20137.

DOI:10.1002/ajim.20137

PMID:15776474

Abstract

BACKGROUND

Wood dust was designated as a human carcinogen based on increased sinus and nasal cancer rates among exposed workers. However, data on an association with lung cancer have been inconclusive.

METHODS

Self-reported wood dust exposure was compared between 1,368 lung cancer patients and 1,192 cancer-free adults, in a lung cancer case-control study. Epidemiological information was collected through a detailed personal interview.

RESULTS

Using several definitions of wood dust exposure we consistently observed statistically significant elevated adjusted risk estimates; for example, the adjusted odds ratio (OR) for combined wood dust related occupations and industries was 3.15 (95% confidence intervals (CI) 1.45-6.86) and for an overall summary exposure measure it was 1.60 (95% CI 1.19-2.14). The association was maintained when stratified by histopathological type. Among those exposed to cigarette smoke and wood dust, 21% of the cases were attributable to biologic interaction.

CONCLUSIONS

Wood dust exposure is a potential risk factor for lung cancer.

摘要

背景

基于暴露工人鼻窦癌和鼻癌发病率增加，木尘被认定为人类致癌物。然而，关于其与肺癌关联的数据尚无定论。

方法

在一项肺癌病例对照研究中，比较了1368例肺癌患者和1192例无癌成年人自我报告的木尘暴露情况。通过详细的个人访谈收集流行病学信息。

结果

使用木尘暴露的几种定义，我们始终观察到经调整的风险估计值在统计学上显著升高；例如，与木尘相关的职业和行业合并后的调整优势比（OR）为3.15（95%置信区间（CI）1.45 - 6.86），总体综合暴露测量的调整优势比为1.60（95%CI 1.19 - 2.14）。按组织病理学类型分层时，该关联依然存在。在暴露于香烟烟雾和木尘的人群中，21%的病例可归因于生物相互作用。