Synthesis of 7-O-[2,6-dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)- alpha-L-talopyranosyl]daunomycinone.
作者信息
Takagi Y, Sohtome H, Tsuchiya T, Umezawa S, Takeuchi T
机构信息
Institute of Bioorganic Chemistry, Kawasaki, Japan.
出版信息
J Antibiot (Tokyo). 1992 Mar;45(3):355-62. doi: 10.7164/antibiotics.45.355.
PMID:1577663
Abstract
7-O-[2,6-Dideoxy-2-fluoro-4-O-(3-fluorotetrahydropyran-2-yl)-alpha -L- talopyranosyl]daunomycinones (7a-7c) have been prepared by condensation of 3'-O-benzoyl derivative of 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)daunomycinone with 2,3-difluorotetrahydropyran as the key reaction. Antitumor activities of these compounds are described.
摘要
Zotero 插件